Whether this relationship between cognitive functioning and survival is truly independent, after correction for all known possible confounders, is unknown. However, as the focus of this previous research was prognostic rather than etiologic, important covariates that influence both cognitive functioning and survival may have biased this relationship. Several studies already revealed that these deficits are significantly associated with survival in diffuse gliomas. Additionally, identification of certain molecular or cognitive prognostic markers can lead to new insights in the pathophysiological mechanisms of diffuse glioma.Ĭognitive deficits occur in all different grades of glioma. These prognostic factors are important to personalize treatment and rehabilitation. For high-grade glioma: MGMT promoter methylation status, extent of resection and MMSE (minimal mental state examination) score. Additionally, several prognostic factors for specific grades of tumors were reported: for low-grade glioma, presence of neurologic deficits before surgery (regardless of epilepsy), pre-operative tumor-volume, and midline crossing.

Until now, research yielded several important predictors of survival, including age, Karnofsky performance status, and tumor grade (and histomolecular classification) for both high and low-grade glioma.

Diffuse gliomas (WHO grade II–IV) are progressive primary brain tumors with a variable, but generally poor prognosis, despite recent progress in treatment options.

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